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Anal fissure. Anal cancer forms when a genetic mutation turns normal, healthy cells into abnormal cells. Kiristin Pirie provided assistance with variable coding and the competing hazards analysis, as did Dr Ben Cairns. There are different types of risk factors. If the cause is inflammatory bowel disease or an infection, a person will need medical treatment. An anal fissure is most common when a person has either a dry, hard bowel movement or frequent, loose stool. Smoking has been linked to an increased risk of developing anal cancer.

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